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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
22.12
Human Site:
Y145
Identified Species:
40.56
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
Y145
E
E
V
F
K
I
C
Y
E
E
D
E
N
I
L
Chimpanzee
Pan troglodytes
XP_522169
734
81883
F184
E
E
F
F
N
I
C
F
H
E
N
E
R
V
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
F196
E
E
F
F
N
I
C
F
D
E
N
E
R
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
Y145
E
E
L
F
K
I
C
Y
E
E
D
E
H
I
L
Rat
Rattus norvegicus
P19686
690
77548
Y144
E
E
L
F
K
I
C
Y
E
E
D
E
H
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
Y145
E
E
L
F
K
I
C
Y
E
E
D
E
H
I
L
Chicken
Gallus gallus
XP_420375
688
77848
Y143
E
E
L
F
K
I
C
Y
E
E
D
E
H
I
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
I127
R
C
D
S
Q
T
D
I
S
G
I
L
K
Y
T
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
Y151
E
E
L
F
N
M
C
Y
E
E
D
R
H
I
L
Fruit Fly
Dros. melanogaster
Q07093
676
75644
G138
E
R
A
F
R
C
L
G
T
D
L
Q
E
F
L
Honey Bee
Apis mellifera
NP_001011650
699
78655
G154
V
I
Y
T
A
C
V
G
L
L
E
R
A
F
R
Nematode Worm
Caenorhab. elegans
O02298
688
78384
A155
K
G
V
V
R
E
V
A
R
R
I
Y
D
T
E
Sea Urchin
Strong. purpuratus
P16065
1125
126238
R389
Q
L
L
E
A
L
D
R
T
H
A
A
G
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
53.3
N.A.
53.3
N.A.
86.6
86.6
N.A.
86.6
86.6
N.A.
0
66.6
20
0
6.6
0
P-Site Similarity:
100
73.3
N.A.
80
N.A.
100
100
N.A.
100
100
N.A.
6.6
86.6
40
6.6
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
16
0
0
8
0
0
8
8
8
0
0
% A
% Cys:
0
8
0
0
0
16
62
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
16
0
8
8
47
0
8
0
8
% D
% Glu:
70
62
0
8
0
8
0
0
47
62
8
54
8
0
8
% E
% Phe:
0
0
16
70
0
0
0
16
0
0
0
0
0
16
0
% F
% Gly:
0
8
0
0
0
0
0
16
0
8
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
8
0
0
39
0
0
% H
% Ile:
0
8
0
0
0
54
0
8
0
0
16
0
0
47
0
% I
% Lys:
8
0
0
0
39
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
8
47
0
0
8
8
0
8
8
8
8
0
0
70
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
24
0
0
0
0
0
16
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
8
8
0
0
16
0
0
8
8
8
0
16
16
0
8
% R
% Ser:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
8
0
0
16
0
0
0
0
8
8
% T
% Val:
8
0
16
8
0
0
16
0
0
0
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
47
0
0
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _